产品描述:
D-Serine is the dextrorotary isomer of the non-essential amino acid L-serine and a co-agonist of NMDA receptors.{54313} It is formed by conversion of L-serine by serine racemase and found primarily in the brain.{28640,54314} D-Serine binds to the glycine site of the NMDA receptor and potentiates glutamate-induced currents in oocytes expressing various subunit combinations (EC50s = 0.17-0.32 µM) more potently than glycine.{54313,54314} It reverses deficits in prepulse inhibition with prepulses of 69 and 73 decibels (dB), but not 81 dB, and increases the time spent in the target quadrant of the Morris water maze in mice with a mutant form of serine racemase (SrrY269*) when administered at a dose of 600 mg/kg.{54315} Serum levels of D-serine are decreased in patients with schizophrenia.{54316}