产品描述:
ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist.{52676} It binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays when used at a concentration of 0.01 µM. ITE (1 µM) inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells.{52677,52678} In vivo, ITE (200 µg/animal, i.p.) reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by complete Freund's adjuvant (CFA) and M. tuberculosis.{52679} ITE (80 mg/kg, i.p.) reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model.{52678}