产品描述:
SB-334867 is an antagonist of the orexin 1 receptor (OX1R; KB = 39.8 nM) that is selective for OX1R over OX2R (KB = 1,995.3 nM).{43606} It reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, when administered at a dose of 30 mg/kg.{43607} SB-334867 (10 mg/kg) inhibits orexin-A-induced increases in grooming time in rats.{43606} It increases the seizure threshold in both the maximal electroshock seizure threshold (MEST) and 6 Hz psychomotor seizure test in mice when administered at doses of 30 and 3 mg/kg, respectively.{43608} Intracerebroventricular administration of SB-334867 (0.5-50 nmol) reduces morphine-induced analgesia in the formalin test in rats.{43609} SB-334867 (1.5 to 6 μg, intra-dentate gyrus injection) also reduces acquisition and consolidation of spatial memory in the Morris water maze in rats.{43610}