产品描述:
Calcitonin is a 32-amino acid peptide hormone that lowers blood calcium levels and inhibits bone resorption.{38632,39431} The amino acid sequence of eel calcitonin varies from salmon (Item No. 24410) and human (Item No. 24409) calcitonin at 3 and 16 positions, respectively.{57212} Calcitonin (eel) binds to calcitonin receptor 2 (CTR2) with higher affinity than human, porcine, or rat calcitonin (Kis = 0.01, 2.95, 0.44, and 5.89 nM, respectively, in radioligand binding assays). It inhibits gastric emptying in conscious dogs more potently than human calcitonin when administered at a dose of 10 µg/kg.{57212,57213} Calcitonin (eel) increases the paw withdrawal threshold in a mouse model of carrageenan-induced inflammation when administered at a dose of 0.2 µg/paw.{57214}