产品描述:
Nicergoline is an antagonist of α1-adrenergic receptors (α1-ARs).{59212} It binds to α1-ARs in rat brain membranes (Ki = 12.5 nM) and inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively). In vivo, nicergoline (0.5 µg/kg per minute, i.v.) inhibits pressor responses induced by the α1-AR agonist cirazoline (Item No. 21791) in pithed rats. Nicergoline (32 mg/kg) improves post-ischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia.{59213} It also increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury.{59214}