产品描述:
β-Zearalenol is a mycotoxin, an agonist of estrogen receptor α (ERα), and an active metabolite of zearalenone (Item No. 11353).{27394,31434} β-Zearalenol increases the proliferation of MCF-7 cells that endogenously express ERα (EC50 = 8.49 nM).{31434} It is also an androgen receptor antagonist (IC50 = 23.10 µM for the human receptor). β-Zearalenol (100 µM) decreases path and straight line velocity and cell linearity, as well as increases curvilinear velocity and the levels of acrosome-reacted sperm, in isolated stallion sperm.{27396} α-Zearalenol induces cytotoxicity in isolated phorbol 12-myristate 13-acetate-stimulated pig neutrophils (IC50 = 56.8 µM). It increases intracellular superoxide levels when used at a concentration of 1 µM, and decreases IL-8 supernatant levels in in the same cells at 10 µM.{69470} β-Zearalenol (50 mg/kg) increases uterine weight in immature female mice.{27394}