产品描述:
4'-hydroxy Tamoxifen is an estrogen receptor (ER) antagonist (IC50 = 2.4 nM for the rabbit receptor) and active metabolite of tamoxifen (Item Nos. 13258 | 11629).{54811,31466} It is formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP2B6, and CYP2C19.{31466} 4'-hydroxy Tamoxifen inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 16 µM, respectively).{28444} It reduces the survival percentage of HEC-1A and HEC-1B endometrial cancer cells when used at concentrations of 10 and 100 nM.{31467} Administration of liposomes encapsulating 4'-hydroxy tamoxifen (4 mg/kg twice per week) reduces tumor growth in an RPMI-8226 multiple myeloma mouse xenograft model.{67257}