产品描述:
Sulfisoxazole is a sulfonamide antibiotic and nonpeptide endothelin (ET) receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors, respectively).{47039,47040} It inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, B. subtilis, S. epidermidis, E. coli, and K. pneumoniae (MICs = 1.95, 0.98, 7.81, 62.5, and 7.81 μg/mL, respectively).{47041} Sulfisoxazole inhibits phosphoinositide turnover stimulated by endothelin-1 (ET-1; Item No. 24127) in TE671 cells. It inhibits ET-induced contraction of rat pulmonary artery rings ex vivo when used at concentrations of 0.1 and 1 mM.{47040} Sulfisoxazole (1,000 mg/kg per day) reduces atrial natriuretic peptide levels in myocytes and plasma and increases survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666) as well as blocks MCT-induced increases in pulmonary artery blood pressure when administered at doses of 300 and 1,000 mg/kg.