产品描述:
Cafestol is a natural diterpene which is abundant in unfiltered coffee.{21876,21885} It elevates serum cholesterol and triglycerides in humans, an effect which does not seem to occur in monkeys, hamsters, rats, or gerbils.{21889,21887} Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of farnesoid X receptors and pregnane X receptors.{21886} Cafestol (20 μM) also inhibits the proliferation of human umbilical vein endothelial cells and prevents their migration and tube formation on Matrigel™.{21890}