产品描述:
The mouse constitutive androstane receptor (mCAR), with the retinoid X receptor, binds to the retinoic acid response element to upregulate the expression of proteins that metabolize xenobiotics.{27657} TCPOBOP is an agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors.{27661,27663} Through its effects on mCAR, TCPOBOP potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins.{27659,27662,27658} The action of TCPOBOP on mCAR-mediated gene expression can be repressed by retinoic acids.{27660}