产品描述:
CU-T12-9 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.{58194} It is selective for TLR1/2 over the TLR2/6 heterodimer in a secreted alkaline phosphatase (SEAP) assay at concentrations up to 10 µg/ml using HEK-Blue cells expressing human TLR2 and endogenously expressing both TLR1 and TLR6 and anti-TLR antibodies. CU-T12-9 (5 µM) induces NF-κB signaling in a reporter assay. It also increases nitric oxide (NO) production in RAW 264.7 cells and primary rat macrophages at 3.6 and 0.4 µM, respectively, and TNF-α production in RAW 264.7 cells (EC50 = 0.06 µM).