产品描述:
Platelet-activating factor (PAF) is a biologically active phospholipid that activates platelets, polymorphonuclear leukocytes, monocytes, and macrophages.{939} PAF also increases vascular permeability, decreases cardiac output, induces hypotension, stimulates uterine contraction, and has been implicated in pathological processes, such as inflammation and allergy.{11753} Apafant is a water soluble, selective PAF receptor antagonist that inhibits PAF binding to human PAF receptors with a Ki value of 9.9 nM.{22980} Apafant displays anti-inflammatory, antiangiogenic, and anticancer activity.{22980,22981,16870}