产品描述:
Migrastatin is a bacterial metabolite that has been found in Streptomyces with antimuscarinic and anticancer activities.{60281,60282} It binds to M1-5 muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 µM, respectively) and inhibits calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in SK-N-SH cells (IC50 = 28 µM), as well as in primary rat bladder smooth muscle cells.{60281} Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50 = 10 µg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50 = 29 µM).{60282} It enhances cytotoxicity induced by vinblastine (Item No. 11762) in vincristine-resistant P388/VCR cells.{60283}