产品描述:
Terfenadine is a selective histamine H1-receptor antagonist with anti-allergic effects that lacks central nervous system depressant activity.{32989} It is a prodrug that undergoes extensive first-pass hepatic metabolism by the cytochrome P450 enzyme CYP3A4 to its pharmacologically active metabolite fexofenadine (Item No. 18191).{32988} Terfenadine is reported to be cardiotoxic, inducing QT interval prolongation by blocking cardiac potassium channels.{32990}