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Rosiglitazone (potassium salt)
品牌： Cayman
产品货号： 71742-100 mg
规格： 100 mg

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折后价：

数量： - +
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  • 产品名称:
    Rosiglitazone (potassium salt)
  • 别名:
  • 产品描述:
    Rosiglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ).{8461} It activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM. It induces differentiation of C3H10T1/2 stem cells into adipocytes when used at a concentration of 1 µM. Rosiglitazone is also an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4; IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg knockout (KO) cells, and increases survival in a Gpx4 KO mouse model of ferroptosis when used at a concentration of 0.0125 mg/ml in the drinking water.{60818,43378} It decreases hemoglobin A1c (HbA1c) and fasting blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104) and a high-carbohydrate and high-fat diet when administered at a dose of 4 mg/kg.{16286} Formulations containing rosiglitazone have been used to improve glycemic control in the treatment of type 2 diabetes.
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    395.5
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    316371-84-3
  • 分子式:
    C18H18N3O3S • K
  • 溶解度:
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