产品描述:
Osanetant is a neurokinin-3 (NK3) receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor).{57470} It is selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively).{57473} Osanetant inhibits contractions and acetylcholine release induced by neurokinin B (Item No. 24542) in isolated guinea pig ileal strips in a concentration-dependent manner.{57470} It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma.{57474} Osanetant (5 and 10 mg/kg) increases the duration of social interaction, as well as reduces immobility time in the tonic immobility test, indicating anxiolytic-like and antidepressant-like activities, respectively, in gerbils.{57475}