产品描述:
Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine.{32550} It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.{22877,25803,25806}