产品描述:
Scopine is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine (Item No. 40307).{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}