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Sarpogrelate-d3 (hydrochloride)
品牌: Cayman
产品货号: 33472-5 mg
规格: 5 mg

报价:
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数量: - +
产品详情
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  • 产品名称:
    Sarpogrelate-d3 (hydrochloride)
  • 别名:
  • 产品描述:
    Sarpogrelate-d3 is intended for use as an internal standard for the quantification of sarpogrelate (hydrochloride) (Item No. 24194) by GC- or LC-MS. Sarpogrelate is a selective antagonist of the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 3.02, 269, and 37.2 nM, respectively, for human recombinant receptors expressed in CHO-K1 cells).{39654} It is selective for 5-HT2 (Ki = 70.8 nM) over 5-HT1 (Ki = >26,000 nM), α1-, α2-, and β-adrenergic (Kis = 640-123,800 nM), and muscarinic receptors (Ki = >40,000 nM).{39658} In vitro, it inhibits aggregation of rat whole blood induced by collagen, 5-HT (Item No. 14332) with collagen, and 5-HT with ADP (Item No. 16778; IC50s = 57.7, 0.56, and 22.7 μM, respectively).{39655} In vivo, it inhibits leukocyte-endothelial interactions in the femoral artery induced by a high-fat high-fructose diet (HFFD) in mice when administered at a dose of 5 mg/kg per day.{39656} Sarpogrelate (5 mg/kg per day) decreases ventricular hypertrophy and infarct size in a rat model of myocardial infarction.{39657}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    469
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥99% deuterated forms (d1-d3)
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  • CAS号:
    2934185-00-7
  • 分子式:
    C24H28D3NO6 • HCl
  • 溶解度:
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