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ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
品牌: Cayman
产品货号: 27106-1 mg
规格: 1 mg

报价:
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数量: - +
产品详情
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  • 产品名称:
    ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
  • 别名:
    Adrenocorticotropic Hormone (4-10)|Corticotropin (4-10)
  • 产品描述:
    Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.{45140} ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons.{45140,45141} The amino acid sequence of ACTH (4-10) is common to ACTH and the α- and β-melanocyte stimulating hormones.{45139} ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats.{45142} It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity.{45143} ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.{45141}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    962.1
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • 分子式:
    C44H59N13O10S • XCF3COOH
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