产品描述:
MRS1754 is an adenosine A2B receptor antagonist (Ki = 1.97 nM).{32640} It is selective for adenosine A2B receptors over adenosine A1, A2A, and A3 receptors (Kis = 403, 503, and 570 nM, respectively). In vivo, MRS1754 (0.5-10 mg/kg) increases 28-day survival, as well as decreases peritoneal bacterial growth and plasma levels of IL-6, TNF-α, and MIP-2, in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{59911} MRS1754 (1 mg/kg) reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).{59912}