产品描述:
Rimonabant-d10 is intended for use as an internal standard for the quantification of rimonabant (Item No. 9000484) by GC- or LC-MS. Rimonabant is a cannabinoid 1 (CB1) receptor antagonist (Ki = 5.6 nM).{3133} It is selective for CB1 over CB2 receptors (Ki = >1,000 nM), as well as a panel of 37 other receptors and channels (IC50s = >1,000 nM). Rimonabant (10 µM) inhibits phytohemagglutinin-induced proliferation of isolated human peripheral blood mononuclear cells (PBMCs).{17167} Intraperitoneal administration of rimonabant prevents decreases in body temperature and increases in tail-flick latency induced by the CB1 and CB2 receptor agonist (+)-WIN 55,212-2 (Item No. 10009023) in mice (ED50s = 0.28 and 1.62 mg/kg, respectively) and oral administration reduces body weight in a mouse model of diet-induced obesity when administered at a dose of 10 mg/kg in the drinking water.{3133,17600} Rimonabant (10 mg/kg) decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like activity.{68311} Formulations containing rimonabant have previously been used in the treatment of obesity.