产品描述:
GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor γ (RORγ; IC50 = 17 nM in a transactivation assay).{63393} It is selective for RORγ over RORα.{34217} GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing conditions (IC50 = 3.2 nM). Topical application of GSK2981278 (1% ointment) reduces dermal symptoms in a mouse model of psoriasis induced by imiquimod (Item No. 14956).