产品描述:
HT-2157 is an antagonist of the galanin-3 receptor (GAL3; Ki = 17 nM).{54910} It is selective for GAL3 over GAL1 and GAL2 (Kis = >10 µM for both). HT-2157 (10 µM) induces apoptosis in various cell types, including HL-60 leukemia and BV-2 murine microglial cells, as well as isolated human peripheral blood mononuclear cells (PBMCs).{54911} It decreases operant alcohol, sucrose, and saccharin self-administration in rats when administered at a dose of 30 mg/kg.{54912} HT-2157 (3 and 10 mg/kg) increases drinking in the Vogel punished drinking task and reduces immobility time in the forced swim test in rats, indicating anxiolytic- and antidepressant-like activities, respectively.{54913}