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Urocortin III (human) (trifluoroacetate salt)
品牌： Cayman
产品货号： 24748-1 mg
规格： 1 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Urocortin III (human) (trifluoroacetate salt)
  • 别名:
  • 产品描述:
    Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Item No. 24745), urocortin II (Item No. 24746), frog sauvagine, and piscine urotensin I.{39576} Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III (Item Nos. 24749 | 24750), mouse urocortin II (Item No. 24747), human urocortin (Item No. 24744), and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively). It stimulates cAMP production in CHO cells expressing rat CRF2α and mouse CRF2β (EC50s = 0.16 and 0.12 nM, respectively) as well as cultured anterior pituitary cells expressing endogenous CRF2β. Urocortin III is co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells.{39579} In vivo, urocortin III reduces food intake in a dose- and time-dependent manner in mice with a minimum effective dose (MED) of 0.3 nmol/animal.{41572} It increases swimming time in a forced swim test in mice, indicating antidepressant-like activity.{41573}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    4137.9
  • 产品形式:
    A lyophilized powder
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    357952-09-1
  • 分子式:
    C185H307N53O50S2 • XCF3COOH
  • 溶解度:
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