产品描述:
U-99194 is a dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor).{64335} It is selective for dopamine D3 receptors over the α1-adrenergic receptor (α1-AR; Ki = 8,913 nM for the rat receptor), M1 muscarinic acetylcholine receptor (mAChR), serotonin (5-HT) receptor subtype 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors). U-99194 reverses hypothermia induced by the D3 receptor agonists (+)-7-OH-DPAT or (+)-PD 128907 (Item No. 21235) in rats with half-maximal inhibitory dose (ID50) values of 19.1 and 12.9 mg/kg, respectively. It increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness when administered at a dose of 40 mg/kg.{72252}