产品描述:
Tandospirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{66707} It selectively binds to 5-HT1A receptors (Ki = 0.027 µM) over 5-HT2, 5-HT1B, 5-HT1C, and 5-HT1D receptors (Kis = 1.3, >100, 2.6, and >100 µM, respectively), as well as α1-adrenergic receptors (α1-ARs), α2-ARs, β-ARs, and dopamine D1 and D2 receptors (Kis = 1.6, 1.9, >100, 1.7, and 41 µM, respectively). Tandospirone (0.1-100 µM) reduces forskolin-induced adenylate cyclase activity in rat hippocampal homogenates. In vivo, tandospirone (10 and 20 mg/kg) reduces immobility time in the forced swim test in mice.{66708} Tandospirone (10 mg/kg) increases food intake and overall survival, as well as decreases body weight loss in a Yoshida hepatoma rat model of cancer cachexia.{66709} Formulations containing tandospirone have been used in the treatment of depression.