产品描述:
GP 2a is a cannabinoid 2 (CB2) receptor agonist (Ki = 7.6 nM for the mouse receptor).{67742} It is selective for CB2 receptors over CB1 receptors (Ki = 900 nM for the mouse receptor). GP 2a (5 to 100 nM) induces the CB2 receptor-dependent phosphorylation of ERK1/2 in HL-60 leukemia promyeloblasts. In vivo, GP 2a (4 mg/kg per day) increases the mechanical threshold force to paw withdrawal and the latency to paw withdrawal from a radiant heat stimulus in a mouse model of neuropathic pain induced by spared nerve injury (SNI).{67743} GP 2a inhibits SNI-induced increases in the number of activated spinal microglia and spinal astrocytes in the same mice.