产品描述:
The liver X receptors, LXRα and LXRβ, are nuclear receptors that act as ligand-dependent transcription factors.{24819} They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively.{10881} It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism.{10881,24822,24821} GW 3965 also affects inflammation and pressor responses through LXRα and LXRβ.{10880,24823,24820}