产品描述:
Danicamtiv is a cardiac-specific myosin activator.{69039,69040} It activates human cardiac S1 myosin when used at a concentration of 3 µM but does not activate skeletal or smooth muscle myosin.{69039} It increases sarcomere activity of isolated porcine left ventricular and atrial myofibrils with 50% active concentration values (AC50s) of 6 and 3.6 µM, respectively. Danicamtiv (3 µM) increases calcium sensitivity of isolated porcine skinned left ventricular and atrial fibers. Danicamtiv (2-3 mg/kg) also prolongs systolic ejection time and improves left ventricular ejection fraction and stroke volume in a dog model of heart failure.