产品描述:
CNDAC is a nucleoside derivative and an active metabolite of the prodrug sapacitabine.{51747} It induces chromosomal aberrations in UV41 cells lacking DNA repair endonuclease XPF when used at a concentration of 1 µM. CNDAC is cytotoxic to BRCA1-/- UWB1.289 and BRCA2-/- PEO1 ovarian cancer cells (IC50s = 9.9 and 10.2 nM, respectively).{51748}