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IL-1alpha (mouse) Matched Pair Detection Set
品牌： Adipogen
产品货号： AG-46B-0004-KI01
规格： 1 Set

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  • 产品名称:
    IL-1alpha (mouse) Matched Pair Detection Set
  • 别名:
    Interleukin-1alpha
  • 产品描述:
    The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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    -20°C
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    BLUE ICE
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    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
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