产品描述:
Glabrol is a flavonoid that has been found in G. glabra and has diverse biological activities.{61559,67478,67479,67480,67481,67482} It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 0.51 and 14.1 µM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B), acyl-coenzyme A:cholesterol acyltransferase (ACAT), and diacylglycerol acyltransferase (DGAT; IC50s = 0.31, 24.6, and 8 µM, respectively).{61559,67478,67479,67480} Glabrol is cytotoxic to MCF-7 breast, SW480 colon, and HepG2 liver cancer cells (IC50s = 7.62, 5.15, and 2.83 µM, respectively) and is active against methicillin-resistant S. aureus (MRSA; MIC50 = 2 µg/ml).{67478,67481} It binds to the benzodiazepine receptor (Ki = 1.63 µM) and increases pentobarbital-induced sleep duration in mice when administered at a dose of 50 mg/kg, an effect that can be reversed by the GABAA receptor antagonist flumazenil (Item No. 14252).{67482}