产品描述:
Cucurbitacin IIa is a triterpenoid that has been found in H. amabilis and has diverse biological activities. {68509,68510,68511} It decreases the proliferation of (IC50 = 370 nM), and induces cell cycle arrest at the G2/M phase and apoptosis in, HT-29 colorectal adenocarcinoma cells when used at a concentration of 1 µM.{68509} Cucurbitacin IIa (2.5 µM) induces cell cycle arrest at the G0/G1 phase in LPS-stimulated, but not unstimulated, RAW 264.7 macrophages.{68510} In vivo, cucurbitacin IIa (5 mg/kg) decreases immobility time in the forced swim test and the tail suspension test in a mouse model of intermittent unpredictable stress.{68511}