产品描述:
DSG-PEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycerol (DSG; Item No. 15079).{65693} It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). LNPs containing DSG-PEG(2000) and encapsulating a toll-like receptor 7 (TLR7) and TLR8 agonist and a peptide antigen each conjugated to poly(L-glutamic acid) (PGA) increase the activation of dendritic cells, macrophages, and B cells in the draining lymph node and dendritic cells and B cells in the spleen in mice compared to the non-LNP-encapsulated PGA-conjugated TLR7/8 agonist and peptide antigen.