产品描述:
AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM).{65811} It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces tumor volume alone or in combination with the 5-fluorouracil prodrug capecitabine (Item No. 10487) in CT26 murine colon cancer models when administered at a dose of 150 mg/kg.