产品描述:
Imidacloprid-d4 is intended for use as an internal standard for the quantification of imidacloprid (Item No. 24130) by GC- or LC-MS. Imidacloprid is a broad-spectrum neonicotinoid insecticide that is effective against sucking and biting insects and insects of the Coleopteran and Lepidoptera orders.{42081,42083} It is an agonist of insect acetylcholine receptors (nAChRs) with Ki values of 1.9, 2.1, 290, and 50 nM for M. persicae and D. melanogaster receptors, rat brain membranes, and rat recombinant receptors containing α4β2 subunits, respectively.{42082,33400} Imidacloprid is lethal to M. persicae with LD95 values of approximately 2 and 160 pg/aphid via oral and topical administration, respectively.{42083} It impairs aversive learning and memory retention in honey bees following chronic sublethal exposure of 20.8 ppb.{42084} In a mouse model of high-fat diet-induced obesity, imidacloprid (0.06-6 mg/kg per day) increases body weight gain and adiposity and impairs glucose metabolism without increasing total food intake.{42085} Formulations containing imidacloprid have been used as insecticides in residential, veterinary, and agricultural settings.