产品描述:
N-acetyl-L-Alanine is an endogenous metabolite.{69604,69605,69606} It decreases IFN-γ production induced by radiation-killed M. tuberculosis in natural killer (NK) cells isolated from patients with latent M. tuberculosis infection when used at a concentration of 3 µM.{69604} N-acetyl-L-Alanine (3 µM) also decreases ATP production and glycolytic flux in naïve or radiation-killed M. tuberculosis-exposed isolated human NK cells. Brain levels of N-acetyl-L-alanine are decreased in a rat model of diabetic neuropathic pain induced by streptozotocin (STZ; Item No. 13104).{69605} Increased urine levels of N-acetyl-L-alanine are associated with mutations in the gene encoding aminoacylase-1 (ACY1), an enzyme involved in the hydrolysis of N-acetylated proteins.{69606}