产品描述:
Borofalan is a radiation sensitizer that contains 10B, a stable isotope of boron.{68610} It sensitizes B16/F10 melanoma cells to fast and thermal neutron radiation when used at a concentration of 50 µg/ml. Borofalan (300 mg/kg) selectively accumulates in sarcoma tissues over blood, muscle, skin, liver, and brain tissue in rats.{68611} In vivo, borofalan (803 mg/kg), in combination with radiation, increases mean survival time in an F98 rat glioma model.{68612} Formulations containing borofalan have been used in boron neutron capture therapy (BNCT) of unresectable, locally recurrent head and neck cancer.