产品描述:
B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of α7 nicotinic acetylcholine receptors (nAChRs).{66569,66570} It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human α7 nAChR when used at a concentration of 10 µM.{66570} B-973B (10 mg/kg) decreases paw edema and induces antinociception in the first and second phase of the formalin test in a mouse model of inflammatory pain. It also inhibits tau aggregation induced by seeding with insoluble human tau isolated from a patient with Alzheimer’s disease in primary rat neurons in a concentration-dependent manner.{66571}