产品描述:
Phellopterin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities.{67567,64084,67568} It is an antagonist of GABAA receptors (IC50 = 360 nM for the rat receptor).{67567} Phellopterin (20 µM) decreases LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) from primary rat peritoneal macrophages.{64084} Topical application of phellopterin (1.2 µg/g) accelerates wound healing in a mouse model of diabetes induced by streptozotocin (Item No. 13104).{67568} It increases the levels of mRNA encoding sirtuin 1 (Sirt1) and decreases mRNA encoding intracellular adhesion molecule-1 (Icam-1) in epithelium isolated from mice in the same model.