产品描述:
L-838,417 is a partial agonist of α2-, α3-, and α5 subunit-containing GABAA receptors.{72213} It potentiates GABA-induced currents in LTK- cells expressing α2β3γ2, α3β3γ2, or α5β3γ2 subunit-containing GABAA receptors when used at a concentration of 100 nM. In vivo, L-838,417 (10 mg/kg) increases the mechanical paw withdrawal threshold in a rat model of spinal nerve ligation-induced static allodynia.{72214} It also decreases social avoidance in a novel environment in adult and adolescent rats, indicating anxiolytic-like activity, when administered at doses of 1 and 2 mg/kg, respectively.{72215}