产品描述:
Obovatol is a lignan polyphenol that has been found in M. officinalis and has diverse biological activities.{51606,51605,51604} It inhibits epinephrine- or arachidonate-induced aggregation of isolated rat platelets (IC50s = 59 and 54 µM, respectively).{51606} Obovatol (50 µM) induces cell cycle arrest at the S phase and apoptosis in SW620 colorectal cancer cells.{51605} It reduces tumor volume and weight in a SW620 mouse xenograft model when administered at a dose of 6 mg/kg per day. Obovatol (1 mg/kg per day for three months) decreases hippocampal and cortical amyloid-β (Aβ) 1-42 (Aβ42) fibril formation and reduces latency and distance to escape in the Morris water maze in a Tg2576 mouse model of Alzheimer's disease.{51604}