产品描述:
Lamevudine is an antiviral.{66705} It selectively inhibits wild-type hepatitis C virus (HCV) non-structural protein 5BΔ55 (NS5BΔ55) over NS5BΔ55 harboring a serine-to-threonine substitution at residue 282 (NS5BΔ55S282T; IC50s = 0.07 and 25 µM, respectively). Lamevudine selectively inhibits replication of HCV replicons in wild-type HBI10A cells over HBI10A cells expressing NS5BΔ55S282T (EC50s = 0.3 and 10.1 µM, respectively). In vitro, it reduces the cytopathic effect of positive-strand RNA viruses in the families Flaviviridae (EC50s = 0.3-15 µM) and Picornaviridae (EC50s = 0.5-5.9 µM) but not viruses of the negative-strand RNA virus family Paramyxoviridae. It inhibits the cytopathic effect and reduces virus yields of the Zika virus strain MR766 in infected Vero cells (EC50s = 20 and 9.6 µM, respectively).{66706} It also reduces serum viral load and delays virus-induced morbidity and mortality in AG129 mice, which lack Ifn-α/β and Ifn-γ receptors, infected with Zika virus when administered at a dose of 50 mg/kg per day.