产品描述:
N-trans-Caffeoyltyramine is a hydroxycinnamic acid that has been found in C. sativa and has diverse biological activities.{72240,72242,72241} It decreases hydrogen peroxide-induced lactate dehydrogenase (LDH) release, production of reactive oxygen species (ROS), and apoptosis in PC12 cells when used at concentrations ranging from 5 to 40 µM.{72240} N-trans-Caffeoyltyramine (50 µM) reduces tyrosinase activity and melanogenesis induced by the peptide hormone α-MSH (Item No. 29923) in B16/F10 cells.{72242} In vivo, N-trans-caffeoyltyramine (200 mg/kg) induces intestinal expression of the gene encoding the nuclear transcription factor hepatic nuclear factor 4α (HNF4α) and increases the number of intestinal Paneth cells, a marker of intestinal barrier function, in a mouse model of high-fat diet-induced obesity.{72241}