产品描述:
13C6-6-PPD-quinone is intended for use as an internal standard for the quantification of 6-PPD-quinone (Item No. 38247) by GC- or LC-MS. 6-PPD-quinone is an oxidized derivative of the tire antiozonant and substituted p-phenylenediamine 6-PPD (Item No. 38246).{69375} It is toxic to rainbow trout (O. mykiss) and brook trout (S. fontinalis; LC50s = 0.59 and 1.96 µg/L, respectively) but not to artic char (S. alpinus) and white sturgeon (A. transmontanus; LC50s = >12.7 µg/L for both). 6-PPD-quinone (10 µg/L) induces cell death and germline DNA damage, as well as decreases the number of mitotic cells, in C. elegans gonads.{69376} Urine levels of 6-PPD-quinone are increased in pregnant women compared to non-pregnant adults and children.{69377}