产品描述:
MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib (Item No. 16274) linked to the cereblon inhibitor pomalidomide (Item No. 19877).{69672} It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK degradation in primary X-linked agammaglobulinemia (XLA) cells expressing wild-type BTK or the ibrutinib-resistant mutant BTKC481S. It also induces BTK degradation in patient-derived chronic lymphocytic leukemia (CLL) cells.