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Dapoxetine-d7 (hydrochloride)
品牌: Cayman
产品货号: 40762
规格: 1 mg

报价:
折后价:

数量: - +
产品详情
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  • 产品名称:
    Dapoxetine-d7 (hydrochloride)
  • 别名:
    (S)-(+)-Dapoxetine-d7|Dapoxetine-d7
  • 产品描述:
    Dapoxetine-d7 is intended for use as an internal standard for the quantification of dapoxetine by GC- or LC-MS. Dapoxetine is a selective serotonin (5-HT) reuptake inhibitor (SSRI; IC50 = 10 nM in isolated rat cerebral cortex membranes).{65667} It selectively inhibits 5-HT uptake over norepinephrine or dopamine uptake in cells expressing the human transporters (IC50s = 1.2, 202, and 1,720 nM, respectively).{65668} (S)-Dapoxetine (1 and 80 µg/animal) increases the amplitude of the pudendal motoneuron reflex discharges in a rat model of the ejaculatory expulsion reflex induced by electrical stimulation of the dorsal penis nerves.{69729} It decreases infarct volume and improves motor performance in a rat model of ischemic stroke induced by bilateral common carotid artery occlusion when administered at doses of 30 or 60 mg/kg.{69730} Dapoxetine (5 mg/kg) decreases prostate weight and levels of Tnf-α, inducible nitric oxide synthase (iNos), and Cox-2 in a rat model of testosterone propionate-induced benign prostatic hyperplasia (BPH).{69731} Formulations containing dapoxetine have been used in the treatment of premature ejaculation.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    348.9
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    2699607-47-9
  • 分子式:
    C21H16D7NO • HCl
  • 溶解度:
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