产品描述:
ASP2905 is an inhibitor of voltage-gated potassium channel Kv12.2.{72356} It inhibits potassium currents in CHO cells expressing Kv12.2 (IC50 = 9 nM). ASP2905 is selective for Kv12.2 over 55 transmembrane proteins at 10 µM. It reduces the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) in primary rat hippocampal neurons when used at concentrations of 0.1 and 1 µM. ASP2905 increases dopamine and acetylcholine efflux in the rat medial prefrontal cortex and improves latent learning in the water-finding task in mice.{72357} It also reduces hyperlocomotion induced by phencyclidine (PCP) in mice when administered at doses of 0.03, 0.1, and 0.3 mg/kg and reduces PCP-induced increases in immobility in mice in the forced swim test at 0.01 and 0.1 mg/kg.{72358}