产品描述:
Verrucarin J is a macrocyclic trichothecene that has been found in A. verrucaria and has fungicidal and anticancer activities.{72350,72351,72352} It is active against a variety of plant pathogenic fungi, including B. cinerea, C. coccodes, F. oxysporum, and M. oryzae (MICs = 12.5, 6.3, 50, and 12.5 µg/ml, respectively).{72350} Verrucarin J reduces viability of A549 and NCI H1793 human non-small cell lung cancer (NSCLC) cells (IC50s = 10 and 20 nM, respectively) and induces apoptosis in A549 cells when used at concentrations ranging from 10 to 50 nM.{72351} It reduces the expression of the cancer stem cell genes encoding ALDH1, LGR5, Oct4, and prominin-1, also known as CD133, as well as the Wnt signaling genes encoding Wnt1, β-catenin, Tcf4, and Notch1 in A549 cells. Verrucarin J also reduces the viability, invasion, and migration of HCT116 human colorectal cancer cells overexpressing Akt (Akt/HCT116 cells).{72352} It reduces tumor growth in an Akt/HCT116 mouse xenograft model when administered at a dose of 0.5 mg/kg.